A rheumatology researcher at the University of Iowa has developed a novel technique for detecting women who might be carrying menopausal hormone (MTH) antibodies that put them at risk for serious infections or strokes.
The technique is detailed in the August 14 edition of the journal Proceedings of the National Academy of Sciences.
In a study of more than 9500 women the researcher found that the presence of MTH antibodies in female blood was consistently associated with a significantly higher risk of developing serious infections or strokes in the next three years.
This study demonstrates an important new approach to diagnosing and monitoring women who are at risk for serious infections or strokes due to their high blood levels of T cells said the studys co-senior author Hossein Banaiezabour an associate scientist in the College of Human Medicine at the University of Iowa. With this methodology which incorporates a combination of cRIAs UWI can determine previously unrecognized MTH specific antibodies levels in blood indicating an individuals MTH specific antibody levels were elevated for up to four years prior to their current MTH specific antibody levels. This marker gives physicians an additional way to monitor this population.
In addition in the next three years there was a significantly higher likelihood that a woman would develop a TB (TB) infection vs. a healthy woman. As the womans odds of developing this infection were higher the likelihood of having a stroke and having a stroke was also increased.
The studys lead author Matthew Leung an assistant professor of kinesiology health and rehabilitation sciences and physical medicine and rehabilitation at University of Iowa said more studies are needed to assess the ease of obtaining separation between menopausal symptoms and the risks associated with these symptoms.
If our data are replicating in other sources we may be able to determine disparate symptom thresholds and frequency categories; said Leung.
The U. S. Centers for Disease Control and Prevention estimates that 2. 65 million women and 1. 26 million men contract menopause symptoms each year. Effective clinical treatment can improve gender awareness reduce mortality and costs and help to eliminate the need for hormone therapy for women who are otherwise eligible for hormone therapy.
A Class 5 diagnostic subtype of menopause called menopausal transition is characterized by a rapid loss of sexual interest in menstruating low libido during sexual activity lack of menstrual depression as well as increases in levels of antibodies that can block these breast tender and uterine tissue development some women have caused uterine and ovarian cancer.
For this study UWI researchers focused on 74220 women with MTH levels at normal or greater than 25 ngml. The women were included only because they had normal MTH levels bound plasma levels. Plasma is the material from the blood combined with other tissues that have liquids in them.
The researchers conducted a questionnaire to solicit information on the medical history (including history of urination breast cancer diagnosis and any medicines) appearance of symptoms and any known infections or strokes. Diagnoses were based on the clinical consultation notes of the patient. The women who received multiple diagnoses and underwent multiple testing were included in the study; those who did not received multiple testing but only report one diagnosis or was an out-patient at the point of screening prior to reaching high enough blood levels to differentiate into multiple (cases). Data was collected by Sunday (Sept. 9 2018) during the peak peak of the menopausal transitions in the available sample for analysis.
About UWI Health: Founded in 1824 University of Iowa Health was the first health center in the United States and is the largest private medical center. With more than 26000 members UWI Health has a proven track record of helping physicians provide the highest quality care to patients. In 2019 UWI Health served more than 22500 military and civilian patients 1000 nurses and more than 660 skilled nursing personnel. In addition in 2018 UWI Health received more than 2500 volunteer physicians and more than 6000 intern and resident physicians teachers and researchers.
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