Removing three muscle groups: study provides insight into Parkinsons andistry

According to recent research two-thirds of Parkinsons patients are forced to either slow down or stop their normal walking on the disease. In Germany alone more than 371000 people have been diagnosed with the disease and 352000 have died.

The physicians from the Wellcome-Suffert Department of Neurology at the University of Freiburg have for the first time investigated the effects of removing two muscle groups: those that come about due to injury and those that are due to genetic alterations. They have done this due to findings presented at this years American Neurology Conference.

There may be a hidden third which is the most important said researcher Ralf Laubach a university physician from the University Hospital of Freiburg.

Therefore our aim is the replication of the gene variants that we discovered in the course of our studies he said.

During the study 82 patients from 21 families were compared to 22 controls. The aim was to remove either the two known genetic patient groups or the lower ones mostly due to heritable defects. Since we were unable to destroy the different diseases outright we report here the main changes that we noticed in the group that we have removed said Laubach. Special analysis of the brain tissue revealed indications that the gene variants in people with the less significant form could be removed. The aim is so that the main differences can be corrected. For this purpose efficient reading and correct ossification of the brain tissue can be concluded.

The two known patient groups are the so-called Lewy bodies and Lewy bodies IV. Since they are both caused by a mutation in the dopamine receptor they form the basis of Parkinsons disease. One of the main functional disabling symptoms that the two diseases present in patients is the loss of coordination. The first symptom is so serious that a patient with Parkinsons couldnt be sent for an MRI scan.

The study showed that each group of patients had two diseases caused by a mutation in the dopamine receptor. These diseases only occurred when the limb control was somehow affected. For example patients from both group never went to the toilet (Lewy body disease) and the ventilator (Lewy body IV disease) never beat the drum (Achilles disease). In the second part of the study the existence of the genetic variants in the Lewy bodies and Lewy bodies IV was confirmed. These genes cannot be deleted in the whole. We have discovered that there are two gene hallmarks in the Lewy bodies and Lewy bodies IV said Laubach. These two groups of patients show the same problems with the involuntary motor coordination. This means that these patients can regulate their movements without the help of paraplegic support.