Aerobic exercise on fat cells may help those with a dense gut

A special type of aerobic exercise on fat cells may help people with a dense gut University of Alabama at Birmingham researchers have reported.

The findings are published in Scientific Reports.

The gut cavity is lined with trillions of microbial cells called gut microbiome. While the guts microbial ecosystem acts like a sponge the microbiome keeps bacteria in check. A dense gut however is considered a gut disorder. Metabolic deficits may impair a persons ability to digest food digest sugar and absorb vitamins.

Somaticulus is a metabolic metabolite released by numerous gut microbes. Somaticulus which is produced primarily by fat cells is what keeps them going. Fat cells release much more of this metabolite when exercising and scientists believe that it exhibits similar properties to the exercise-induced elevations in glucose and lipids in cells.

Professor of Integrative Physiology and Metabolism Yuri Yanovsky of the University of Alabama at Birmingham Department of Cell Biology and Pharmacology said the Universitys work is the first to demonstrate a link between aerobic exercise on fat cells and gut microbiome. When the team administered a compound that inhibited CGRP which is a glucagon receptor involved in insulin-like signaling in fat cells the gut microbiome behavior changed. Flowway cells which improve the flow of nutrients-laden fat into the blood decreased by 25 to 50 percent.

The study was conducted in the lab of Dr. Karolina Martina professor in the UAB College of Medicine and her team. It found that CGRP prostituted anaerobic exercise by acting directly on B lymphocytes immune system cells in the gut so that fat cells could more efficiently use sugar and cholesterol.